Total body water is 60 of body weight and is divided into various body fluid compartments. Rapid mixing of tritiated water throughout all compartments occurs during a 3 to 4 hour equilibration period. This is estimated by measuring the volume of distribution of isotopes of water. Not prone to changing the distribution of fluid between compartments. If the amount of the substance is known and the resulting concentration is measured the volume can be calculated. The indicator dilution principle is based on the definition of a concentration.
Measuring total body water with radiolabelled tritium. Tritium oxide tho is used because it is a weak beta emitter making it easy to measure in a liquid scintillation counter. The intracellular fluid icf compartment is the system that includes all fluid enclosed in cells by their plasma membranes. Extracellular fluid compartment further. 20150921 fluid compartments regulation of ecf volume fluid replacement duration. University of kentucky department of anesthesiology 5062 views 2943.
Body fluid compartments can be measured by dilution of a compound that distributes only in the space of interest. Body fluids can be discussed in terms of their specific fluid compartment a location that is largely separate from another compartment by some form of a physical barrier. If one were that way inclined one could also go on to read this indepth article by shoeller etal from 1980 full of thick juicy physiology. These include intracellular fluid and extracellular fluid. 222 total body water. So simple one can describe it using only pictures.